Developmement of Mucoadhesive Buccal Patch Containing Aceclofenac: in Vitro Evaluations

Mucoadhesive buccal patch of Aceclofenac were prepared using polymer like Gelatin, Poly Sodium CMC and Poly Vinyl Alcohol. Eight formulations were prepared with varying the concentration of Poly Sodium CMC and evaluated for various parameters like weight variation, patch thickness, volume entrapment efficiency %, and measurement of % elongation at break, folding endurance, in vitro mucoadhesive time, in vitro release and stability study. The formulations showed a sustained release. The F5 formulation containing Aceclofenac 6%, Gelatin 4.5%, Poly Sodium CMC 5.5%, Propylene Glycol 5%, Poly vinyl Alcohol 2.5% and Distilled Water up to 100%, showed a release of 88.4% after 8 hours. The Aceclofenac stability studies were performed at 40 ± 2 C / 75 ± 5% RH. Among the eight formulation, F5 formulation showed maximum desired properties release.